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. 2021 Aug 2;9(8):e002547. doi: 10.1136/jitc-2021-002547

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© Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.

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clinical response data of cohort 1 and 2. (A) Usual vulvar intraepithelial neoplasia (uVIN) lesions visible at screening visit. (B) Partial response of uVIN lesions visible at follow-up +12 months after vaccination with human papillomavirus-16 E6/E7 tattoo vaccination. (C) Overview of uVIN lesion size changes (as percentage change compared with baseline) during follow-up. (D) Waterfall plot showing percentage change of uVIN lesion at last follow-up compared with baseline lesion size (=lesion size at screening). (E) Lesion size before therapy per response category. Complete responders are depicted in green, partial responders in orange and non-responders in red. CR, complete response; NR, non-responder; PR, partial response.