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. 2021 Jul 30;36(1):1702–1714. doi: 10.1080/14756366.2021.1945049

Figure 11.

Figure 11.

General strategy for hybridisation of CAIs with cytotoxins in compounds of type C. CA IX/XII–cytotoxic agent hybrids, incorporate toxic payloads 28–32, whereas the CA inhibitory warheads may be benzenesulphonamide or 1,3,4-thiadiazole-2-sulphonamide derivatives (although coumarins and other CAI chemotypes can be used). The linker is usually a tetrapeptide incorporating water-solubilizing residues (Asp, Arg, Cys).