Table 1.
Lectins tested for antiviral activity against SARS-CoV-2 pseudovirus.
| Lectin | Mw (kD) | ka (1/Ms) | kd (1/s) | KD (M) | IC50 (μg/mL) | haemagglutination activity (μg/mL) | CC50 (μg/mL) | SI |
|---|---|---|---|---|---|---|---|---|
| WGA | 38.4 | 3.21E+06 | 4.82E-03 | 1.50E-09 | 8.5 ± 0.6 | >7.81 | >500 | >58.8 |
| SSL | 133.7 | 2.81E+04 | 8.86E-04 | 3.15E-08 | 73.6 ± 8.1 | >0.98 | >500 | >6.8 |
| Lentil lectin | 52.5 | 1.06E+05 | 9.19E-04 | 8.67E-09 | 8.9 ± 0.9 | >500 | >500 | >56.2 |
| Peanut lectin | 98.8 | na | na | na | >100 | >1000 | >500 | na |
| MAL | 122.1 | na | na | na | >100 | >7.81 | >500 | na |
| PHA-L | 109.2 | 6.97E+04 | 2.62E-03 | 3.76E-08 | 22.0 ± 1.8 | >3.91 | >500 | >22.7 |
| PHA-P | 150.8 | 1.54E+05 | 5.01E-03 | 3.25E-08 | 75.2 ± 5.2 | >31.25 | >500 | >6.6 |
| PHA-M | 118.1 | 7.89E+03 | 1.96E-02 | 2.48E-06 | 53.8 ± 10.3 | >31.25 | >500 | >9.3 |
| PHA-E | 118.4 | 2.07E+04 | 3.31E-03 | 1.60E-07 | 20.2 ± 3.5 | >3.91 | >500 | >24.8 |
| DSL | 68.4 | 1.75E+06 | 1.44E-03 | 8.23E-10 | 84.0 ± 10.0 | >0.49 | >500 | >6.0 |
| succ-Con A | 51.2 | 7.37E+00 | 1.48E-03 | 2.01E-04 | 33.8 ± 3.9 | >1000 | >500 | >14.8 |
| GNL | 40.3 | 7.92E+05 | 1.21E-03 | 1.53E-09 | 72.0 ± 3.4 | >0.5 | >500 | >6.9 |