TABLE 3.

Change From Baseline in Corneal Fluorescein Staining: Total and Subregions

	NOV03 QID–Saline*	NOV03 BID–Saline*
	Point Estimate of Mean Difference (95% CI); P	Point Estimate of Mean Difference (95% CI); P
tCFS
Week 2	−0.86 (−1.39 to −0.32); 0.002	−0.65 (−1.19 to −0.11); 0.018
Week 4	−1.28 (−1.91 to −0.65); <0.001	−1.29 (−1.93 to −0.66); <0.001
Week 8	−1.18 (−1.81 to −0.55); <0.001	−0.85 (−1.49 to −0.22); 0.009
Central
Week 2	−0.27 (−0.45 to −0.08); 0.004	−0.24 (−0.42 to −0.06); 0.010
Week 4	−0.29 (−0.49 to −0.08); 0.006	−0.33 (−0.53 to −0.13); 0.002
Week 8	−0.29 (−0.48 to −0.10); 0.003	−0.22 (−0.41 to −0.03); 0.025
Temporal
Week 2	−0.11 (−0.27 to 0.06); 0.197	−0.11 (−0.27 to 0.05); 0.192
Week 4	−0.38 (−0.56 to −0.19); <0.001	−0.30 (−0.49 to −0.11); 0.002
Week 8	−0.29 (−0.47 to −0.11); 0.001	−0.20 (−0.38 to −0.02); 0.028
Inferior
Week 2	−0.15 (−0.33 to 0.03); 0.098	−0.12 (−0.31 to 0.06); 0.181
Week 4	−0.24 (−0.44 to −0.04); 0.020	−0.19 (−0.40 to 0.01); 0.064
Week 8	−0.27 (−0.46 to −0.08); 0.006	−0.13 (−0.33 to 0.06); 0.179

^*For mean treatment difference in CFB.