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. 2021 Jul 20;12:697411. doi: 10.3389/fphar.2021.697411

TABLE 4.

The active compounds from medicinal plants most often used in combinations in medical species and probability of predicted antidiabetic mechanisms assitiated with these compounds.

Medicinal plant/ (abbreviation) Active compound Mechanism of action Pa Pi
Vaccinium myrtillus L. (VM) Isoorientin Antidiabetic 0.806 0.005
Vitexin-2"-rhamnosid α-glucosidase inhibitor 0.854 0.001
Antidiabetic 0.767 0.005
Inositol Sugar-phosphatase inhibitor 0.961 0.002
Phaseolus vulgaris L. (PV) Isoorientin Antidiabetic 0.806 0.005
Myricetin Lipid peroxidase inhibitor 0.836 0.003
β-glucuronidase inhibitor 0.679 0.005
Eleutherococcus senticosus (Rupr. & Maxim.) Maxim. (ES) Syringin Antidiabetic 0.684 0.007
Hypolipemic 0.674 0.016
Eleutheroside E Sugar-phosphatase inhibitor 0.887 0.005
Hypericum perforatum L. (HP) Hyperoside Antidiabetic 0.661 0.008
Lipid peroxidase inhibitor 0.976 0.002
Sugar-phosphatase inhibitor 0.874 0.006
α-glucosidase inhibitor 0.842 0.001
Aralia elata (Miq.) Seem (AE) Araloside A Antidiabetic 0.639 0.009
Hypolipemic 0.955 0.003
Insulin promoter 0.753 0.004
Araloside B Lipid peroxidase inhibitor 0.969 0.002
Hypolipemic 0.953 0.003
α-glucosidase inhibitor 0.932 0
Araloside C Hypolipemic 0.952 0.003
Fragaria vesca L. (FV) Taxifolin-3-O-arabinofuranoside Antidiabetic 0.617 0.011
Lipid peroxidase inhibitor 0.95 0.002
Antihypercholesterolemic 0.901 0.003
Urtica dioica L. (UD) 2-O-caffeoylmalic acid Lipid metabolism regulator 0.836 0.005
Quercetin p-coumaroyl glucoside Lipid peroxidase inhibitor 0.978 0.002
α-glucosidase inhibitor 0.729 0.001
Galega officinalis L. (GO) Galegine Sugar-phosphatase inhibitor 0.632 0.047
Glucose oxidase inhibitor 0.691 0.025
Phytol Lipid metabolism regulator 0.828 0.005
Hypolipemic 0.68 0.015
Taraxacum campylodes G.E.Haglund. (TC) Taraxacin β-glucuronidase inhibitor 0.619 0.011
Rosa spp. (Rsp) Lycopene Sugar-phosphatase inhibitor 0.794 0.017
Lipid metabolism regulator 0.880 0.004
Arctium spp. (Asp) Arctigenic acid Insulin promoter 0.579 0.017
Vaccinium vitis-idaea L. (VVI) Hydroquinone Sugar-phosphatase inhibitor 0.906 0.004
Inulinase inhibitor 0.690 0.004
Mentha × piperita L. (MP) Menthol Insulin promoter 0.773 0.004
Sugar-phosphatase inhibitor 0.804 0.016
Linum usitatissimum L. (LU) Gallic acid Sugar-phosphatase inhibitor 0.941 0.003
Glucan endo-1.6-beta-glucosidase inhibitor 0.933 0.002