Table 1.
Loci attaining genome-wide significant (P < 5 × 10−8) association with eGFR after meta-analysis of GPC and WHI in up to 11 512 individuals of African ancestry
| Uganda | WHI | Meta-Analysis | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Locus | Lead SNP | Chr | BP (b37) | EA | NEA | Beta | SE | MAF | P-value | Beta | SE | P-value | MAF | P-value | N |
| GATM | rs2433603 | 15 | 45 646 226 | T | C | 0.145 | 0.025 | 48% | 1.0 × 10−8 | 1.0276 | 0.3042 | 7.3 × 10−4 | 47% | 2.4 × 10−9 | 11 512 |
| HBB | rs141845179 | 11 | 5 244 665 | G | T | 0.266 | 0.048 | 8% | 3.0 × 10−8 | NA | NA | NA | NA | 3.0 × 10−8 | 3288 |
SNP, single nucleotide polymorphism; Chr, Chromosome; BP, base position; EA, effect allele; NEA, Non-effect allele; SE, standard error; NA, not available.