Table 1. Baseline characteristics by degree of polypharmacy.

Characteristic+	No polypharmacy (n = 738,923,785)	Minor polypharmacy (n = 341,779,401)	Moderate polypharmacy (n = 256,247,011)	Major polypharmacy (n = 779,309,084)
Age (years), median (IQR)	74 (69–80)	73 (68–79)	73 (68–80)	75 (70–81)
Female sex, %	55.5	57.5	56.1	57.5
Race, %
White	66.2	62.5	66.0	67.2
Black/African American	5.7	6.0	7.2	6.4
Other	4.3	4.7	4.0	2.9
More than one race	0.1	0.1	0.2	0.2
Hispanic or Latino ethnicity, %	7.1	7.7	7.9	6.1
Chronic conditions, median (IQR)	0 (1–2)	2 (1–3)	2 (1–3)	3 (2–4)

⁺ All comparisons between no polypharmacy vs. minor polypharmacy vs. moderate polypharmacy vs. major polypharmacy groups were deemed statistically significant if p<0.0001