Table 1. Baseline demographic and clinical characteristics of the patients according to immune status, and of patients with solid organ cancer, haematologic cancer and solid organ transplant.
| Non-IS | IS | P | SO cancer | Haematologic cancer | SO transplant | |
|---|---|---|---|---|---|---|
| Sex | ||||||
| Male | 6253 (56.4) | 1253 (59.4) | 0.014 | 695 (64.3) | 227 (63.4) | 99 (59.6) |
| Female | 4831 (43.5) | 854 (40.4) | 383 (35.4) | 131 (36.6) | 66 (39.8) | |
| Unknown | 11 (0.1) | 4 (0.2) | 3 (0.3) | 0 (0) | ||
| Age (years): mean (SD) | 66.5 (16.6) | 71.0 (13.6) | <0.001 | 73.2 (12.3) | 71.0 (14.1) | 63.5 (13.3) |
| Smoking status | ||||||
| Never | 7553 (68.1) | 1192 (56.5) | <0.001 | 565 (52.3) | 214 (59.8) | 105 (63.2) |
| Former | 2481 (22.4) | 676 (32.0) | 382 (35.3) | 106 (29.6) | 50 (30.1) | |
| Current | 534 (4.8) | 142 (6.7) | 87 (8.0) | 24 (6.7) | 5 (3.0) | |
| Unknown | 527 (4.7) | 101 (4.8) | 47 (4.3) | 14 (3.9) | 6 (3.6) | |
| Obesity | ||||||
| No | 7910 (71.3) | 1547 (73.3) | 0.127 | 813 (75.2) | 262 (73.2) | 131 (78.9) |
| Yes | 2180 (19.6) | 376 (17.8) | 179 (16.6) | 61 (17.0) | 32 (19.3) | |
| Unknown | 1005 (9.1) | 188 (8.9) | 89 (8.2) | 35 (9.8) | 3 (1.8) | |
| Dependency level | ||||||
| No/mild | 9203 (82.9) | 1677 (79.4) | <0.001 | 833 (77.1) | 286 (79.9) | 144 (86.7) |
| Moderate | 944 (8.5) | 282 (13.4) | 159 (14.7) | 45 (12.6) | 15 (9.0) | |
| Severe | 808 (7.3) | 123 (5.8) | 73 (6.7) | 22 (6.1) | 2 (2.4) | |
| Unknown | 140 (1.3) | 29 (1.4) | 16 (1.5) | 5 (1.4) | 3 (1.8) | |
| Charlson comorbidity index | ||||||
| 0–1 | 8484 (76.5) | 378 (17.9) | <0.001 | 0 (0) | 1 (0.3) | 51 (30.7) |
| 2–3 | 1713 (15.4) | 885 (41.9) | 455 (42.1) | 216 (60.3) | 57 (34.3) | |
| 4–5 | 431 (3.9) | 348 (16.5) | 220 (20.3) | 72 (20.1) | 30 (18.1) | |
| > = 6 | 182 (1.6) | 425 (20.1) | 363 (33.6) | 58 (16.2) | 25 (15.1) | |
| Unknown | 285 (2.6) | 75 (3.6) | 43 (4.0) | 11 (3.1) | 3 (1.8) | |
| Comorbidities* | ||||||
| Arterial hypertension | 5434 (49.0) | 1239 (58.7) | <0.001 | 648 (59.9) | 198 (55.3) | 120 (72.3) |
| Chronic heart failure | 726 (6.5) | 217 (11.3) | <0.001 | 107 (9.9) | 42 (11.7) | 17 (10.2) |
| COPD | 688 (6.2) | 236 (11.2) | <0.001 | 136 (12.6) | 31 (8.7) | 9 (5.4) |
| Asthma | 820 (7.4) | 145 (6.9) | 0.338 | 58 (5.4) | 16 (4.5) | 9 (5.4) |
| Dementia | 1120 (10.1) | 190 (9.0) | 0.131 | 109 (10.1) | 26 (7.3) | 7 (4.2) |
| Chronic liver disease** | 79 (0.7) | 55 (2.6) | <0.001 | 31 (2.9) | 5 (1.4) | 14 (8.4) |
| Chronic renal failure** | 554 (5.0) | 245 (11.6) | <0.001 | 110 (10.2) | 32 (8.9) | 78 (47.0) |
| Diabetes mellitus | 2017 (18.2) | 509 (24.1) | <0.001 | 263 (24.3) | 82 (22.9) | 57 (34.3) |
| Total | 11095 | 2111 | 1081 | 358 | 166 |
Values are shown as n (%) unless stated otherwise. Percentages might not add up to 100% due to rounding. Non-IS: non-immunosuppressed patients. IS: immunosuppressed patients. COPD: chronic obstructive bronchopulmonary disease.
*Comorbidity values are not mutually exclusive (any given patient could have several comorbidities).
**Moderate to severe.
P-values for differences in proportions between immunosuppressed and non-immunosuppressed groups are also shown.