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. 2021 Jul 22;17(7):e1009691. doi: 10.1371/journal.pgen.1009691

Fig 1. Region CS38-40 is a sub-TAD boundary of the HoxD locus.

Fig 1

(A, B) Hi-C of the HoxD locus in wild-type (A) and del(CS38-40) (B) whole limbs at E12.5. Topological domains (TADs or sub-TADs) were identified using a window size (w) of 240 kb (light-coloured bars) or 480 kb (dark-coloured bars) and are represented below each Hi-C heatmap. (C) Insulation scores computed with two different window sizes (see above). (D) Wild-type ChIP-seq of CTCF in E12.5 whole limbs. CTCF orientations are indicated by red or blue arrowheads. (E) Magnification of region CS38-40 (mm10, chr2:75122684–75160161; highlighted in light green in previous panels) from panel D. The extension of the deletion in del(CS38-40) (mm10, chr2:75133816–75153815) is shown as a dashed line at the bottom.