Table 1.
Classification of mammalian type A and type B HATs, their substrates, and cellular localization
| Family | Member name | Typology | Histone and non-histone substrates | Localization |
|---|---|---|---|---|
| GNAT | HAT1 (KAT1) HAT4 (NAA60) GNC5 (KAT2A) PCAF (KAT2B)ELP3 (KAT9)ATAT-1 (MEC-17) |
type-B type-B type-A type-A |
H4, H2A H4, H2A H3, H4, H2A, CDC6, CDK9, cyclin D1, cyclin E1 and E2F1, HDM2, PTEN, c-myc, TBX5, PLK4, CEBPB H3, H4, p53, CDK9, c-myc, Foxo1, AR, TBX5, PLK4, ACLY H4, H2A, H3 α-Tubulin, cortactin |
Nucleus, cytosol Cytosol Nucleus Nucleus Cytosol |
| p300/CBP | CBP (KAT3A) p300 (KAT3B) |
type-A type-A |
NF-kappaB, c-myb, Foxo1, NCOA3, PCNA, KLF1, transcription factor MafG, IRF-2 H2A, H2B, H3, NF-kappaB, c-myc, p53, STAT3, β-catenin, Foxo1, AR, ALX1, SIRT2, HDAC1, BCL6, MTA1, XBP1 isoform 2, PCNA, MEF2D, ZBTB7B |
Nucleus Nucleus |
| MYST | Tip60 (KAT5) MOZ (KAT6A) MORF (KAT6B) HBO1 (KAT7) MOF (KAT8) |
type-A type-A type-A type-A type-A |
H4, H2A, ATM, TRRAP, E2F1, c-myc, NR1D2, FOXP3, RAN H3, p53 H3, H4 H4, p53 |
Nucleus Nucleus Nucleus Nucleus Nucleus |
| Nuclear receptor coactivators | SRC-1 | H3, H4 | Nucleus | |
| Transcription factor complexes | TAF1/TBP (KAT4) TFIIIC90 (KAT12) |
H3, H4 H3 |
Nucleus Nucleus |