Table 2.

Bisubstrate inhibitors of type A and B HATs

Compound	Inhibition (IC50)
	Type A HATs target		Type B HATs target
H3-CoA-20	200 µM (p300)	0.3 µM (Kd 0.028) (PCAF)
Lys-CoA	0.5 µM (Kd 0.019) (p300)	200 µM (PCAF)
Lys-CoA	3.2 µM (p300)
Lys-CoA	0.05 µM (p300)
Lys-Phe-CoA	0.7 µM (p300)
Lys-CoA-Me	0.8 µM (p300)
Lys-CoA-3ʹ-dephospho	1.6 µM (p300)
H4K5CoA			0.083 µM (HAT1)
H4K8CoA			2.6 µM (HAT1)
H4K12CoA			0.023 µM (HAT1)
H4K16CoA			7.2 µM (HAT1)