Table 3.

Associations between sleep and dietary patterns and DNA methylation of circadian genes in Mexican adolescents, overall description

	Number of probes in gene	Proportion of probes with association P < 0.05	Number of probes in islands	Proportion of island probes with P < 0.05	Direction of island probe association (majority)
Sleep Midpoint (median of bed and wake time)
BMAL	64	0.016	9	0.11	+
CLOCK	43	0.023	13	0
CRY1	28	0	11	0
CRY2	32	0.094	8	0
NR1D1	22	0.091	12	0.17	+
NR1D2	26	0.077	10	0
PER1	19	0.11	5	0
PER2	39	0	6	0
PER3	34	0	15	0
RORA	192	0.063	28	0.18	+
RORB	26	0.038	4	0.25	+
RORC	23	0	0	0
Diet pattern 1: Plant-based and lean proteins
BMAL1	64	0.016	9	0
CRY1	28	0	11	0
CRY2	32	0	8	0
CLOCK	43	0.023	13	0
NR1D1	21	0.048	11	0
NR1D2	26	0	10	0
PER1	19	0.053	5	0.2	-
PER2	39	0.103	6	0
PER3	34	0.059	15	0.07	-
RORA	192	0.010	28	0.04	-
RORB	26	0	4	0
RORC	23	0	0	0
Diet pattern 2: Meat & starchy foods
BMAL1	64	0.047	9	0.11	+
CLOCK	43	0.023	13	0.08	-
CRY1	28	0.036	11	0.09	+
CRY2	32	0.031	8	0
NR1D1	21	0	11	0
NR1D2	26	0.077	10	0.1	+
PER1	19	0.053	5	0.2	-
PER2	39	0	6	0
PER3	34	0	15	0
RORA	192	0.026	28	0.04	+
RORB	19	0.053	4	0
RORC	23	0	0	0
Diet pattern 3: Eggs, milk & refined grain
CLOCK	43	0.163	13	0
BMAL1	64	0.141	9	0.11	-
CRY1	28	0.071	11	0
CRY2	32	0.063	8	0.13	-
NR1D1	21	0.190	11	0.27	-
NR1D2	26	0.154	10	0.3	-
PER1	19	0.158	5	0.2	-
PER2	39	0.103	7	0.17	-
PER3	34	0.088	15	0
RORA	192	0.005	28	0.14	-
RORB	26	0.038	4	0
RORC	23	0.087	0	0