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. 2021 Jul 30;13(1):1946918. doi: 10.1080/19420862.2021.1946918

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© 2021 Taylor & Francis Group, LLC

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 5. — VRC01-class antibodies: neutralization potency and breadth against multiclade panel of viruses and serum half-life in human FcRn transgenic mice. (a) Summary of neutralization potency and breadth of VRC01-class antibodies against a panel of 208 pseudoviruses (b) Scattered plots of neutralization potency and breadth with black bars representing median IC₅₀s. A horizontal dotted line extending from the median IC₅₀ of VRC07-523-W54-LS.v3 was drawn as a reference for comparison. (c) Pharmacokinetics of VRC01-class antibodies in human FcRn transgenic mice. Error bars represent SD