Table 4.
Drinking water – protocols for antibiotic-induced gut depletion
| DURA-TION | ANTIBIOTIC COCKTAILS CONCENTRATIONS | DISEASES (ICD 10) |
PUBLICA-TIONS |
|---|---|---|---|
| 2 days | streptomycin (500 g/ L) | Diseases of the circulatory system (Stroke) | 32 |
| ciprofloxacin (0.2 g/L) + metronidazole (1 g/L) |
Endocrine, nutritional and metabolic diseases (Obesity) | 33 | |
| 5 days | ampicillin (0.5 g/L) | Infectious disease | 34 |
| 1 week | ampicillin (1 g/L) | GI disorder (due to antibiotic- and chemotherapy-induced gut dysbiosis) | 35 |
| 1 or 2 weeks | amoxicillin–clavulanic acid (1 g/L) |
Diseases of the circulatory system (Stroke) | 36 |
| 7 days | Systemic antibiotic cocktail: ampicillin (1 g/L) + cefoperazone sodium salt (1 g/L) + clindamycin (1 g/L) OR Non-absorbable antibiotic cocktail: ertapenem sodium (1 g/L) + neomycin sulfate (1 g/L) + vancomycin hydrochloride (1 g/L) |
FMT protocol | 37 |
| 7 days | ampicillin (0.01 g/1 L) + metronidazol (0.01 g/L) + neomycin (0.01 g/L) |
Diseases of the digestive system (Hepatic steatosis) | 38 |
| 10 days | vancomycin (1 g/L) + metronidazole (1 g/L) + polymyxin B (1 g/L) + cefotaxime (2 g/L) |
FMT protocol | 39 |
| cefoxitin (1 g/L) + gentamicin (1 g/L) + metronidazole (1 g/L) + vancomycin (1 g/L) |
Immune system | 40 | |
| 10–14 days | ampicillin (1 g/L) + metronidazole (1 g/L) + neomycin sulfate (1 g/L) + vancomycin (0.5 g/L) |
Infectious disease | 41 |
| 14 days | ampicillin (1 g/L) + metronidazole (1 g/L) + neomycin (1 g/L) + vancomycin (0.5 g/L) |
Immune system | 42 |
| 14 days | ampicillin (1 g/L) + metronidazole (1 g/L) + neomycin sulfate (1 g/L) |
Diseases of the nervous system (Alzheimer's disease) | 43 |
| 14 days | ampicillin (1 g/L) + metronidazole (1 g/L) + neomycin (1 g/L) + vancomycin (0.5 g/L) supplemented with 1% (wt/vol) glucose. |
Immune system | 44 |
| 14 days | ampicillin (1 g/L) + metronidazole (1 g/L) + neomycin (1 g/L) + vancomycin (0.5 g/L) |
Endocrine, nutritional and metabolic diseases (Obesity) | 45 |
| 14 days | ampicillin (1 g/L) + metronidazole (1 g/L) + neomycin sulfate (1 g/L) |
Mental and behavioral disorders (Depression) | 46 |
| 14 days | ampicillin (1 g/L) + vancomycin (0.5 g/L) + neomycin (1 g/L) + metronidazole (1 g/L) |
Antibiotic effects | 47 |
| 2–3 weeks | ampicillin (1 g/l) + streptomycin (5 g/l) + colistin (1 mg/ml) or vancomycin alone (0.25 g/L) or imipenem alone (0.25 g/L) or colistin alone (2.103 U/ml) |
Neoplasms (Cancer) | 48 |
| 2–3 weeks | ampicillin (1 g/L) + vancomycin (0.5 g/L) + neomycin (1 g/L) + metronidazole (1 g/L) |
Infectious diseases | 49 |
| 3 weeks | ampicillin (1 g/L) + neomycin (1 g/L) + streptomycin (1 g/L) + kanamycin (1 g/L) and/or anti-fungal cocktail drinking water amphotericin (0.2 g/L) + fluconazole (0.5 g/L) + 5-fluorocytosine (0.5 g/L) |
Infectious diseases | 50 |
| 3 weeks | ampicillin (1 g/L) + metronidazole (1 g/L) + neomycin sulfate (1 g/L) + vancomycin (0.5 g/L) |
Infectious diseases | 51 |
| 3 weeks | vancomycin (0.5 g/l) + ampicillin (1 g/l) + kanamycin (1 g/l) + metronidazole(1 g/l) |
Immune system | 52 |
| 3 weeks | ampicillin (1 g/L) + metronidazole (1 g/L) + neomycin (1 g/L) + vancomycin (0.5 g/L) |
Immune system | 53 |
| 3 weeks | vancomycin (0.5 g/L) + neomycin sulfate (1 g/L)+ ampicillin (1 g/L) + metronidazole (1 g/L) |
Immune system | 54 |
| 3 weeks | ampicillin (1 g/L) + metronidazole (1 g/L) + vancomycin (0.5 g/L) + neomycin trisulfate (1 g/L) |
Diseases of the digestive system | 55 |
| 4 weeks | ampicillin (1 g/L) + vancomycin (0.5 g/L) + polymyxin (0.1 g/L) |
Immune system | 56 |
| 4 weeks | ampicillin (1 g/L) + neomycin (1 g/L) + metronidazole (1 g/L) + vancomycin (0.5 g/L) |
Diseases of the musculoskeletal system and connective tissue | 57 |
| 4 weeks | vancomycin (0.5 g/L) + neomycin (1 g/L) + ampicillin (1 g/L) + metronidazole (1 g/L) |
Diseases of the digestive system | 58 |
| 4 weeks | ampicillin (1 g/L) + neomycin (1 g/L) + metronidazole (1 g/L) + vancomycin (0.5 g/L) or vancomycin (0.5 g/L) alone |
Bone formation | 59 |
| 4–5 weeks | ampicillin (1 g/L) + neomycin (0.5 g/L) + streptomycin (0.5 g/L) + vancomycin (0.5 g/L) |
Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism | 60 |
| 7 weeks | ampicillin (1 g/L) + vancomycin (0.5 g/L) + ciprofloxacin (0.2 g/L) + imipenem plus cilastatin (250 mg/L) + metronidazole (1 g/L) |
Mental and behavioral disorders (depression) | 61 |