Appendix 8—table 2. Best combinations of biomarkers associated with severe or moderate dengue for children.
| Best of all combinations | Best combination of 2 variables | Best combination of 3 variables | Best combination of 4 variables | Best combination of 5 variables | |
|---|---|---|---|---|---|
| Variables | |||||
| - VCAM-1 | |||||
| - SDC-1 | + | ||||
| - Ang-2 | + | + | + | + | |
| - IL-8 | + | + | |||
| - IP-10 | + | + | + | ||
| - IL-1RA | + | + | + | + | + |
| - sCD163 | |||||
| - sTREM-1 | |||||
| - Ferritin | + | + | + | + | + |
| - CRP | |||||
| - Viremia | |||||
| AIC of the selected model | 465.9 | 484.7 | 480.0 | 473.7 | 467.6 |
VCAM-1: vascular cell adhesion molecule-1; SDC-1: syndecan-1; Ang-2: angiopoietin-2; IL-8: interleukin-8; IP-10: interferon gamma-induced protein-10; IL-1RA: interleukin-1 receptor antagonist; sCD163: soluble cluster of differentiation 163; sTREM-1: soluble triggering receptor expressed on myeloid cells-1; CRP: C-reactive protein; AIC: Akaike information criterion.