Table 3. Best combinations of biomarkers associated with severe or moderate dengue for children.
| Best of all combinations | Best combination of 2 variables | Best combination of 3 variables | Best combination of 4 variables | Best combination of 5 variables | |
|---|---|---|---|---|---|
| Variables | |||||
| - VCAM-1 | |||||
| - SDC-1 | + | ||||
| - Ang-2 | + | + | + | + | |
| - IL-8 | + | + | |||
| - IP-10 | + | + | + | ||
| - IL-1RA | + | + | + | + | + |
| - sCD163 | |||||
| - sTREM-1 | |||||
| - Ferritin | + | + | + | + | + |
| - CRP | |||||
| AIC of the selected model | 465.9 | 484.7 | 480.0 | 473.7 | 467.6 |
| Bootstrap results | |||||
| - Model selection frequency, n (%) | 134 (13.4) | 437 (43.7) | 239 (23.9) | 317 (31.7) | 440 (44.0) |
| - Rank by selection frequency of the selected model | 1 | 1 | 2 | 1 | 1 |
VCAM-1: vascular cell adhesion molecule-1; SDC-1: syndecan-1; Ang-2: angiopoietin-2; IL-8: interleukin-8; IP-10: interferon gamma-induced protein-10; IL-1RA: interleukin-1 receptor antagonist; sCD163: soluble cluster of differentiation 163; sTREM-1: soluble triggering receptor expressed on myeloid cells-1; CRP: C-reactive protein; AIC: Akaike information criterion.