Table 12.

Comparison of drug binding motifs of analyzed NSPs for antiviral drugs

	7K3N (Nsp1)	6WEY (Nsp3)	6M03 (Nsp5)	7JLTNsp7-8	6W4B (Nsp9)	6ZCTNsp10	6M71 (Nsp7/8/12)	7NIO Nsp13	5C8S (Nsp14)	6VWW (Nsp15)	7BQ7 Nsp16-10	Total binding sites
Amphetamine			+									1
Amprenavir	+  +  +	+  +  +  +		+  +			+  +  +	+  +  +	+  +  +	+  +	+  +	22
Atazanavir	+					+  +	+	+	+	+	+  +  +	10
Darunavir	+  +  +  +  +   +  +  +  +  +	+  +  +  +  +  +	+  +	+		+  +  +	+  +  +  +	+  +	+  +  +  +  +  +  +	+  +  +  +  +	+  +  +  +  +	45
Grazoprevir					+	+  +			+		+  +	6
Indinavir	+		+			+	+	+  +  +	+	+  +  +	+	12
Lopinavir						+		+  +	+  +	+  +  +	+	9
Nelfinavir	+  +		+	+			+  +	+			+	8
Nevirapine			+									1
Ribavirin			+		+							2
Rimantadine	+	+  +	+  +  +	+	+  +  +		+	+  +	+  +  +  +  +		+  +	20
Ritonavir			+			+		+			+  +	5
Saquinavir	+  +	+		+		+	+  +  +	+	+  +	+  +  +	+  +  +  +	18
Tipranavir	+	+  +	+		+		+  +	+	+  +	+	+	12

Among fourteen drugs four (Amprenavir, Darunavir, Rimantadine, Saquinavir) have very significant and the other two (Indinavir, Tipranavir) have moderatenumber of binding motifs. ‘ + ’ sign indicates no. of drug binding motifs