Table 3.
Antibacterial activity of acetic acid 1 and its synthesized derivatives 2–7, complexes 8–11 and nucleosides 15–17 in mm
| Gram positive | Gram negative | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Staphylococcus aureus | Enterococcus faecalis | Escherichia coli | Pseudomonas aeruginosa | |||||||||||||||||
| Compounds | Inhibition zone | Inhibition zone | Inhibition zone | Inhibition zone | ||||||||||||||||
| a | b | c | d | e | a | b | c | d | e | a | b | c | d | e | a | b | c | d | e | |
| 1 | – | – | – | – | – | – | – | – | – | – | 7 | – | – | – | – | – | – | – | – | – |
| 2 | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| 3 | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| 4 | 34 | 26 | 12 | – | – | 12 | 8 | – | – | – | – | – | – | – | – | – | – | – | – | – |
| 6 | 8 | – | – | – | – | – | – | – | – | – | – | – | – | – | – | 7 | – | – | – | – |
| 7 | 32 | 18 | – | – | – | 7 | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| 8 | 8 | – | – | – | – | – | – | – | – | – | 9 | – | – | – | – | – | – | – | – | – |
| 9 | 21 | 18 | 14 | 13 | – | – | – | – | – | – | 24 | 23 | 19 | 18 | 14 | 9 | 8 | 8 | – | – |
| 10 | 7 | – | – | – | – | – | – | – | – | – | 9 | – | – | – | – | – | – | – | – | – |
| 11 | 20 | 18 | 16 | 14 | 14 | 11 | 9 | 8 | – | – | 21 | 19 | 19 | 18 | 14 | 13 | – | – | – | – |
| 15 | 21 | 14 | 16 | 12 | 8 | 19 | 12 | 10 | – | – | 7 | – | – | – | – | – | – | – | – | – |
| 16 | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | 12 | – | – | – | – |
| 17 | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| * | 18 | – | – | – | – | 17 | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| ** | – | – | – | – | – | – | – | – | – | – | 16 | – | – | – | – | 14 | – | – | – | – |
| DMSO | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
a,b,c,d,e: concentrations: (10, 10/2, 10/4, 10/8, 10/16) mg/mL.,respectively
Key to the inhibition zones activities: ( −) for no inhibition or undone, Highly active=Inhibition zone > 15 mm; Moderately active=Inhibition zone 10–15 mm; Slightly active=Inhibition zone 6–8 mm; Inactive=Inhibition zone < 6 mm
*Vancomycin, **Colistin