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. 2021 Aug;9(8):897–908. doi: 10.1016/S2213-2600(20)30448-3

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© 2021 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

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Lung function over time in the per-protocol population

(A) Mean FEV₁%. (B) Mean FVC. Please note the varying y-axes. HDTs were given until day 112, except for ergocalciferol, for which administration ceased on day 56. The symbols indicate timepoints that differ significantly from control after adjusting for differences at baseline. FEV₁=forced expiratory volume in 1 s. FVC=forced vital capacity. HDT=host-directed therapy. *Everolimus at day 180. †CC-11050 at day 180. ‡Auranofin at day 84. §Ergocalciferol at day 14.