Table 5.

The impact of enzyme-inducing antiseizure medications on the odds of direct oral anticoagulant levels below the expected range (n = 152)

Model	ADS	EI-ASM	Moderate inhibitor
A	0.16 (0.02–1.06)	–	–
B	0.80 (0.49–1.31)	6.11 (2.19–17.0)*	–
C	0.79 (0.48–1.28)	6.26 (2.19–17.9)*	0.23(0.05–1.09)

Data are presented as odds ratio (95% confidence interval). Model A evaluated the association of levels below the range with apixaban dose score using a mixed-effects logistic regression model. Model B included terms for apixaban dose score and the presence of EI-AMSs. Model C included terms for apixaban dose score, EI-ASMs, and moderate CYP3A4 inhibitors

ADS apixaban dose score, CYP cytochrome P450, EI-ASM enzyme-inducing antiseizure medications

*p < 0.001