Table 3.

Effectiveness and safety endpoints by creatinine clearance

	Total	Normal renal function group (CrCl ≥ 50 mL/min)	Renal dysfunction group (CrCl < 50 mL/min)	P value†
	(n = 6806)	(n = 5326)	(n = 1480)
Effectiveness endpoint
Stroke/Systemic embolism	164 (0.98)	112 (0.85)	52 (1.47)	< 0.001
Ischemic stroke	121 (0.72)	81 (0.61)	40 (1.13)	0.001
All-cause death	270 (1.61)	136 (1.03)	134 (3.79)	< 0.001
Safety endpoint
Major bleeding	206 (1.23)	138 (1.05)	68 (1.92)	< 0.001
Non-major bleeding	815 (4.87)	633 (4.80)	182 (5.15)	0.474

Figures are number of event (%/year)

CrCl creatinine clearance

^†CrCl ≥ 50 mL/min vs. CrCl < 50 mL/min