Table 1.
Baseline characteristics of subjects with normal kidney function and four levels of kidney impairment (mild, moderate, or severe impairment, and requiring hemodialysis)
| Normal [n = 15] | Mild [n = 8] | Moderate [n = 8] | Severe [n = 5] | RH [n = 8] | Total [N = 44] | |
|---|---|---|---|---|---|---|
| Sex [n (%)] | ||||||
| Male | 8 (53.3) | 6 (75.0) | 4 (50.0) | 2 (40.0) | 5 (62.5) | 25 (56.8) |
| Female | 7 (46.7) | 2 (25.0) | 4 (50.0) | 3 (60.0) | 3 (37.5) | 19 (43.2) |
| Age, years | ||||||
| Mean (SD) | 46.3 (12.6) | 62.9 (8.1) | 57.0 (8.6) | 53.8 (13.2) | 44.5 (10.6) | 51.8 (12.6) |
| Range (min–max) | 28–64 | 48–74 | 44–68 | 32–66 | 28–55 | 28–74 |
| Height, m | ||||||
| Mean (SD) | 1.74 (0.10) | 1.73 (0.08) | 1.69 (0.09) | 1.70 (0.12) | 1.74 (0.09) | 1.72 (0.09) |
| Range (min–max) | 1.59–1.90 | 1.59–1.85 | 1.57–1.85 | 1.55–1.84 | 1.57–1.83 | 1.55–1.90 |
| Weight, kg | ||||||
| Mean (SD) | 80.2 (19.6) | 88.8 (15.6) | 86.9 (16.7) | 75.7 (12.1) | 78.4 (19.1) | 82.1 (17.4) |
| Range (min–max) | 57.6–114.6 | 64.0–108.5 | 65.5–116.9 | 65.5–95.0 | 49.2–108.0 | 49.2–116.9 |
| BMI, kg/m2 | ||||||
| Mean (SD) | 26.1 (4.2) | 29.6 (4.4) | 30.3 (3.1) | 26.1 (3.2) | 25.7 (5.4) | 27.4 (4.5) |
| Range (min–max) | 19.5–32.1 | 24.8–35.0 | 26.0–34.2 | 20.5–28.1 | 20.0–34.8 | 19.5–35.0 |
| GFR, mL/min | ||||||
| Mean (SD) | 121 (16) | 74 (12) | 44 (9) | 22 (3) | NA | 80 (41) |
| Range (min–max) | 98–149 | 63–89 | 34–59 | 19–26 | NA | 19–149 |
| eGFR, mL/min/1.73m2 | ||||||
| Mean (SD) | 105 (12) | 54 (10) | 31 (9) | 15 (3) | 10 (6) | 55 (40) |
| Range (min–max) | 81–124 | 40–68 | 21–49 | 11–18 | 4–25 | 4–124 |
| CLCr, mL/min | ||||||
| Mean (SD) | 126 (23) | 69 (14) | 44 (6) | 22 (6) | 17 (8) | 69 (47) |
| Range (min–max) | 97–179 | 56–91 | 35–55 | 15–32 | 8–35 | 8–179 |
BMI body mass index, eGFR estimated glomerular filtration rate, GFR glomerular filtration rate, CLCr estimated creatinine clearance, min minimum, max maximum, n number of subjects, NA not applicable, RH requiring hemodialysis, SD standard deviation