Table 1.
Baseline characteristics and subject demographics
| Normal renal function [N = 14] | Mild renal impairment [N = 8] | Moderate renal impairment [N = 8] | Severe renal impairment [N = 7] | ESRD [N = 8] | Overall [N = 45] | |
|---|---|---|---|---|---|---|
| Age, years | 58.1 ± 7.6 | 63.3 ± 6.6 | 68.8 ± 14.1 | 60.3 ± 9.3 | 52.9 ± 7.2 | 60.3 ± 10.1 |
| Sex, male | 9 (64.3) | 5 (62.5) | 4 (50.0) | 6 (85.7) | 6 (75.0) | 30 (66.7) |
| Ethnicity | ||||||
| Hispanic or Latino | 2 (14.3) | 5 (62.5) | 3 (37.5) | 4 (57.1) | 0 (0.0) | 14 (31.1) |
| Non-Hispanic or non-Latino | 12 (85.7) | 3 (37.5) | 5 (62.5) | 3 (42.9) | 8 (100.0) | 31 (68.9) |
| Race | ||||||
| American Indian or Alaska Native | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) |
| Asian | 0 (0.0) | 0 (0.0) | 2 (25.0) | 0 (0.0) | 0 (0.0) | 2 (4.4) |
| Black or African American | 7 (50.0) | 2 (25.0) | 3 (37.5) | 1 (14.3) | 8 (100.0) | 21 (46.7) |
| Native Hawaiian or other Pacific Islander | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) |
| White | 7 (50.0) | 6 (75.0) | 3 (37.5) | 6 (85.7) | 0 (0.0) | 22 (48.9) |
| Weight, kg | 88.0 ± 11.2 | 93.1 ± 19.8 | 83.8 ± 18.1 | 81.8 ± 8.1 | 89.6 ± 14.7 | 87.5 ± 14.4 |
| Height, cm | 175.3 ± 10.3 | 170.7 ± 7.9 | 169.3 ± 8.9 | 173.9 ± 6.2 | 178.0 ± 7.2 | 173.7 ± 8.7 |
| BMI, kg/m2 | 28.6 ± 2.6 | 31.7 ± 4.5 | 29.0 ± 4.2 | 27.2 ± 4.1 | 28.3 ± 4.4 | 29.0 ± 3.9 |
| With T2D | 0 (0.0) | 2 (25.0) | 1 (12.5) | 2 (28.6) | 1 (12.5) | 6 (13.3) |
Data are expressed as n (%) or mean ± SD
BMI body mass index, ESRD end-stage renal disease, N total number of subjects in the specified treatment group, n number of subjects in the specified category, SD standard deviation, T2D type 2 diabetes