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. 2021 Aug 4;36(8):109570. doi: 10.1016/j.celrep.2021.109570

Figure 1.

Figure 1

Development of humoral and cellular immunity after BNT162b2 vaccination

(A and B) Quantification of IFN-γ (Α) and IL-2 production (B) in naive and COVID-19 recovered individuals (pre-vaccination [pre], 10 and 20 days after the first vaccine dose [10 and 20, respectively], and 10 and 20 days after the second vaccine dose [30 and 40, respectively]) after overnight stimulation of whole blood with SARS-CoV-2 peptide pools. IFN-γ and IL-2 concentration levels were determined using ELLA single plex cartridges (n = 92 individuals; 47 naive and 45 COVID-19 recovered).

(C) Kinetics of SARS-CoV-2 spike-specific IgG serum levels in naive and COVID-19 recovered individuals measured by ACCESS SARS-CoV-2 CLIA. For IgG, IFN-γ, and IL-2 determination, the group means method was used to compare pre-treatment versus post-treatment time points and also among post-treatment time points. All individual time points were measured using technical triplicates. A two-sample t test assuming unpaired populations for pre- and post-treatment was performed for each of the markers, separately for the COVID-19 recovered and naive cohorts. The p value for the test statistic was set to the 0.05 level of significance, and the Benjamini-Hochberg (BH) method was used for multiple testing correction.