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. 2021 Aug 4;799:149456. doi: 10.1016/j.scitotenv.2021.149456

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© 2021 The Authors

Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.

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Fig. 5 — Proportion of Spike gene RNA fragments containing the N501Y mutation in wastewater from Amsterdam (A) and Utrecht (B) calculated as relative concentration of N501Y containing Spike gene fragments divided by the total concentration of S-gene fragments (WT + N501Y). Error bars are calculated assuming Poisson distribution of RNA molecules in droplets. The proportion of newly COVID-19 patients infected with N501Y containing variants (Pathogen genomic surveillance) are shown as (the proportional sum of lineages B.1.1.7, B.1.351 and P.1).