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. 2021 Jul 21;27:1609784. doi: 10.3389/pore.2021.1609784

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Copyright © 2021 Xu, Yuan, Wang, Chen, Zhang and Zhang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Methylation landscape of 407 CRC samples in the TCGA-COAD dataset. (A) Line graph of total within sum of square (Y-axis) vs. cluster number (X-axis) obtained through the within-cluster sum of squares method which defined the optimal cluster number as 7. (B) K-means cluster analysis of the 407 CRC samples based on their Euclidean distance calculated through β values of the 3,561 CpG sites with the cluster number specified as 7. (C) Kaplan-Meier curves of CRC samples stratified by their cluster. (D) Kaplan-Meier curves of CRC samples in cluster 4 (CIMP group) and other clusters (noCIMP). Abbreviations: CRC, colorectal cancer; CRMP, CpG island methylator phenotype (CIMP).