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. 2021 Jul 21;27:1609784. doi: 10.3389/pore.2021.1609784

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Copyright © 2021 Xu, Yuan, Wang, Chen, Zhang and Zhang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Differential methylation and expression analysis. (A) Volcano plot of logarithmic-transformed FDR (Y-axis) vs. logarithmic-transformed fold change of gene expression values (X-axis). Red, blue, and green dots represent downregulated, upregulated, and non-differential expression genes in CRC samples, respectively. (B) Venn diagram of hyper-methylation and downregulated expression genes in CRC samples. Hyper-methylation genes are defined as genes containing at least one hyper-methylation CpG site.