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. 2021 Jul 13;10(7):401–410. doi: 10.1302/2046-3758.107.BJR-2020-0200.R2

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© 2021 Author(s) et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (CC BY-NC-ND 4.0) licence, which permits the copying and redistribution of the work only, and provided the original author and source are credited. See https://creativecommons.org/licenses/by-nc-nd/4.0/.

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Fig. 1 — Poly (ADP-ribose) polymerase 1 (PARP-1) activity in the cartilage of osteoarthritis (OA) rats and effects of intra-articular injection of PARP-1 shRNA (short hairpin (sh)-PARP-1). a) Real-time quantitative reverse transcription polymerase chain reaction (RT-qPCR) was used to analyze the messenger RNA (mRNA) expression levels of PARP-1 in the cartilage of OA rats at different timepoints after anterior cruciate ligament transection (ACLT) plus medial meniscus removal (MMx) surgery. N = 5 in each group at each timepoint. b) RT-qPCR was used to analyze the mRNA expression levels of PARP-1 in the cartilage of OA rats at different timepoints after intra-articular injection of sh-PARP-1. NC, negative control. N = 5 in each group at each timepoint. Data are presented as mean (standard deviation (SD)). **p < 0.01, ***p < 0.001 compared to sham or control. One-way analysis of variance (ANOVA) followed by Dunn's multiple comparisons test for b), and two-way ANOVA followed Tukey's multiple comparisons test for a).