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. 2021 Jul 13;10(7):401–410. doi: 10.1302/2046-3758.107.BJR-2020-0200.R2

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© 2021 Author(s) et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (CC BY-NC-ND 4.0) licence, which permits the copying and redistribution of the work only, and provided the original author and source are credited. See https://creativecommons.org/licenses/by-nc-nd/4.0/.

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Fig. 6 — Effects of intra-articular injection of poly (ADP-ribose) polymerase 1 (PARP-1) shRNA (short hairpin (sh)-PARP-1) on the expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) in cartilage of rats 12 weeks after anterior cruciate ligament transection (ACLT) plus medial meniscus removal (MMx). a) and d) Real-time quantitative reverse transcription polymerase chain reaction (RT-qPCR) was used to analyze the messenger RNA (mRNA) expression levels of iNOS and COX-2 in cartilage. b) and e) Western blotting was used to assay the protein expression of iNOS and COX-2 in the cartilage. c) and f) Relative expression levels of iNOS and COX-2 are shown, which were normalized to the corresponding sham. N = 12 in each group. Data are presented as mean (standard deviation (SD)). **p < 0.01, ***p < 0.001 between the indicated groups. One-way analysis of variance (ANOVA) followed by Dunn's multiple comparisons test. OA, osteoarthritis.