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. 2021 Jul 7;53(7):1134–1147. doi: 10.1038/s12276-021-00645-4

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a Trains of APs induced in dentate GCs of control (black) and CBKO mice (red) by 1 s depolarizing current injections as indicated by numbers left to the traces. b The F–I curves in the control (black, n = 9) and CBKO (red, n = 8) mice. c Example traces of the first AP elicited by 300 pA current injection from control (black) and CBKO (red) GCs. d Bar graphs showing the onset time, threshold, overshoot amplitude, and half-width of the first AP elicited by 300 pA current injection measured from CBKO (red) and control (black). e Trains of APs induced in CA1 of control (black) and CBKO (red) by 100 pA, 1 s depolarizing current injection. f Bar graph for AP frequency at 100 pA current injection in CA1 cells of control and CBKO mice. Data are represented as the mean ± SEM. **P < 0.01, ***P < 0.001, N.S. (not significant) P > 0.05 by Student’s t test.