Fig. 5. The P_i-bound dwell and alternative P_i path.

a Cryo-EM map of the P_i-bound dwell. b Zoomed in section of the P_i-bound dwell with the ADP molecule from the catalytic-dwell ${\beta }_{320^{\circ }}$ site docked and shown as spheres with CPK coloring. The alternative P_i exit channel (black dashed arrow with a minimum diameter of 9 Å) could facilitate dissociation of the P_i (corresponding map in orange and circled), while MgADP remains bound (also see Supplementary Fig. 6).