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. 2021 Aug 3;11:15689. doi: 10.1038/s41598-021-95214-0

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Mitochondrial and peroxisomal free fatty acid and acyl-CoA transport. Differential expression of genes associated with fatty acid transport assessed by RNA-seq. Mouse Genome Informatics (MGI) official gene symbols are used. (A) The presence of putative dioxin response elements (pDREs) and AHR genomic binding at 2 h. (B) Time-dependent expression following a single bolus dose of 30 μg/kg TCDD (n = 3). (C) Dose-dependent gene expression assessed following oral gavage every 4 days for 28 days with TCDD (n = 3). (D) Diurnal regulated gene expression denoted with a “Y”. An orange ‘X’ indicates abolished diurnal rhythm following oral gavage with 30 μg/kg TCDD every 4 days for 28 days. ZT indicates statistically significant (P1(t) > 0.8) time of maximum gene induction/repression. Counts represent the maximum number of raw aligned reads for any treatment group. Low counts (< 500 reads) are denoted in yellow with high counts (> 10,000) in pink. Differential gene expression with a posterior probability (P1(t)) > 0.80 is indicated by a black triangle in the top right tile corner. Protein subcellular locations were obtained from COMPARTMENTS and abbreviated as: cytosol (C), endoplasmic reticulum (ER), lysosome (L), mitochondrion (M), outer mitochondrial membrane (OMM), inner mitochondrial membrane (IMM), nucleus (N), peroxisome (P), and plasma membrane (PM). The heatmap was created using R (v4.0.4).