Fig. 3. Canine tumor alteration landscape, consisting of genes recurrently mutated and/or amplified/deleted, varies with tumor types but not with breeds in general.
a Oncoprints indicate the top six most recurrently altered genes with nonsynonymous somatic base substitutions or small indels (top), or copy number alterations (CNAs) (bottom), in CDS regions in each tumor type indicated. Significant recurrence, identified by Fisher exact tests with multiple testing correction60, are denoted by “*” as shown. The breed of each animal is specified in the breed bar. b Enrichment scores of the most recurrently altered genes and pathways, obtained via Fisher exact test q-values (see “Method”), in each tumor type of all breeds (left) and of Golden Retriever (middle), as well as in each breed with ≥10 dogs within a tumor type (right). Source data are provided as a Source Data file.