Table 2:
Docking model | Top 1 | Top 3 |
---|---|---|
RLDOCK30 | 55.3% | 60.5% |
DOCK625b | 36.8% | 44.7% |
rDock43c | 28.9% | 47.4% |
rDock_solv43c | 39.5% | 55.3% |
AutoDock Vina44d | 31.6% | 44.7% |
A prediction is successful if the best RMSD of the top binding modes is less than 2.0Å with respect to the native binding mode.
The data is obtained from Ref. 24.
For rDock and rDock solv, the cavity is defined using the reference ligand method, the radius of outer sphere is set as 5, and a final 50 runs-per-ligand rDock job is performed.
The centroid of the native ligand binding pose is set as the center of the docking box. The size of the docking box is set as 20Å ×20Å ×20Å