Fig. 1. Evoked DA response monitored with FSCV in dorsal striatum show increment during MAO-A inhibition, while less change at MAO-B inhibition.

a Schematic design of triangular waveform from fast cyclic voltammetry (FSCV). b Experimental schedule for FSCV recordings. c–e The representative phasic dopamine changes in the striatum detected by FSCV in response to treatment with saline control, MAO-A inhibitor (clorgiline, 10 mg kg⁻¹), and MAO-B inhibitor (KDS2010, 10 mg kg⁻¹). Pseudo-color plots indicate the phasic dopamine responses before (left) and after 120 mins (middle) from drug administration. The time-series plot of each evoked DA response was extracted at the dopamine oxidation potential (right). The black line and red line show the concentration change before and after drug injection, respectively. f Time-dependent change in the peak DA current. g Quantification of estimated DA concentrations from peak DA current. MAO-A inhibition increased phasic DA level to 284%, while MAO-B inhibition did not (n = 6 mice for each group). h Summary bar graph of the decay time constant K calculated from the time-series plots at the oxidation voltage (0.6 V). Data represent mean ± SEM. *P < 0.05; ***P < 0.001; ns, non-significant by one-way ANOVA with Tukey’s multiple comparison test.