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. 2021 Aug 3;11:15701. doi: 10.1038/s41598-021-95209-x

Table 3.

Association between events during stay at the ICU and markers measured in COVID-19 patients.

Event Analysis Unit Event present Event not present AUC P
Dialysis Yes (13) No (87)
sAXL Day 1 ng/ml 11.7 (9.1–19.6) 19.3 (13.9–25.2) 0.021
ROC curve 0.301 (0.158–0.443 0.029
VTE Yes (14) No (86)
NE Day 1 ng/ml 40.9 (20.0–66.2) 83.4 (40.7–143.9) 0.019
Delirium Yes (9) No (70)
Gas6 Day 1 ng/ml 31.1 (23.8–38.5) 23.2 (16.2–30.3) 0.033
ICUAW Yes (9) No (91)
cfDNA Day 1 ng/µl 699.5 (273.1–1130.4) 246.6 (139.1–466.9) 0.019
ROC curve 0.786 (0.566–0.909) 0.009

Indicated is the event and significant altered plasma markers. The difference at day 1 or the delta is calculated with Mann–Whitney U and the predictive power of an event by a marker is calculated by the AUC of the ROC curve. Values are considered significant if p < 0.05.

VTE various thromboembolic events, ICUAW Intensive Care Unit Acquired Weakness, ROC receiver operating characteristic, AUC area under the curve.