Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Jul 20;53(7):1170–1179. doi: 10.1038/s12276-021-00652-5

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2021, corrected publication 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 4 — a The enhanced production of S100A9 induced by various stimuli was evaluated by ELISA. b The effects of LPS and IFN-γ on the production of S100A9 by M0 macrophages were evaluated by ELISA. c The concentrations of proinflammatory cytokines released from M0 macrophages after S100A9 stimulation. d Immunofluorescent staining for CD68 (red) and iNOS (green) in M0 macrophages. Scale bar, 25 μm. e The expression of S100A9-induced iNOS and Arginase 1 was quantified by western blotting. f Enhanced Smad 3 signaling in A549 cells induced by M1 macrophages. g The LPS-induced S100A9 release from A549 cells was augmented by M1 macrophages. The data are presented as the means ± SD. *P < 0.050, **P < 0.010, ***P < 0.001 were obtained by one‐way ANOVA with Bonferroni’s post hoc test. HC healthy control, iNOS inducible nitric oxide synthase, IFN-γ interferon-gamma, IL interleukin, LPS lipopolysaccharide, M1 M1 macrophage, NSA non-severe asthma, S100A9 S100 calcium-binding protein A9, SA severe asthma, TNF-α tumor necrosis factor-α.