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. 2021 Aug 3;11:15754. doi: 10.1038/s41598-021-94456-2

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© The Author(s) 2021, corrected publication 2021

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Timeline of the experimental paradigm. Timeline of each assessment pre- and post-thermal stimuli with primary stimulus (at 25 °C) and secondary stimulus (at 5 °C). The cold test was induced by the immersion of the right hand in the water for 30 s or until feeling the first pain sensation with both stimuli and a break of 2 min between each trial.