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. 2021 Aug 3;11:15754. doi: 10.1038/s41598-021-94456-2

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© The Author(s) 2021, corrected publication 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Representative waveforms from cortical activation at right PFC (A); left PFC (B) and left motor cortex (C). Figures shows waveforms from cortical activation of an illustrative subject with fibromyalgia or one control. They showed waveforms of oxyhemoglobin (HbO) by fNIRS upon to primary (25 °C) or secondary (5 °C) stimulus. The figure presents both sides left and right prefrontal cortex (PFC). (A) Peak latency represents the maximum peak (time in seconds) and HbO millimolar. (B) (ΔHbO) [steady-state HbO before thermal primary or secondary stimuli onset minus the absolute value of peak HbO] (mM). (C) The cortical activation 15 s after thermal stimuli end by the variability of absolute HbO concentration [the difference between the delta value of HbO (Δ-HbO) 15 s from thermal stimuli end and Δ-HbO before thermal stimuli onset (Δ-HbO*)].