Table 1.
Effect of TQ and/or BP treatment on serum levels of liver damage parameters in fluvastatin-induced hepatitis in rats.
| Parameters | Control (G1) | F (G2) | F + TQ (G3) | F + BP (G4) | F + TQ + BP (G5) |
|---|---|---|---|---|---|
| ALT (U/L) | 39.54 ± 3.64e | 180.11 ± 7.30a | 81.2 ± 6.83c | 109.66 ± 6.57b | 62.48 ± 4.23d |
| AST (U/L) | 137.49 ± 6.71e | 375.45 ± 10.49a | 216.06 ± 8.69c | 252.58 ± 9.52b | 171.54 ± 7.13d |
| ALP (U/L) | 89.37 ± 5.27e | 281.34 ± 13.01a | 162.14 ± 7.01c | 208.26 ± 8.17b | 111.36 ± 6.11d |
| γ-GTP (U/L) | 7.06 ± 0.62d | 25.33 ± 1.20a | 15.85 ± 0.64b | 17.76 ± 0.81b | 10.36 ± 0.54c |
| Albumin (g/dl) | 4.12 ± 0.23a | 2.05 ± 0.12d | 3.00 ± 0.13c | 2.71 ± 0.16c | 3.59 ± 0.14b |
| Total bilirubin (mg/dl) | 0.95 ± 0.07d | 3.32 ± 0.14a | 2.12 ± 0.13bc | 2.44 ± 0.11b | 1.63 ± 0.09c |
Data are expressed as mean ± SEM (n = 7/group). Mean values with different superscript letters [a (the highest values) – e (the lowest value)] in the same row are significantly different at (p ≤ 0.05). All groups were compared to each other. BP, Bee pollen; G1-5, Groups 1–5; F, Fluvastatin; TQ, Thymoquinone.