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. 2021 Aug 3;12:4676. doi: 10.1038/s41467-021-24963-3

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a Cryo-EM structures of Nb17 in complex with S. b Nb17:RBD interactions are mediated by all three CDRs. c Cryo-EM structure of the Nb17:Nb105:RBD complex. d Nb17 structurally does not overlap with ACE2. e Cryo-EM structure of the Nb36:Nb21:RBD complex. f Epitope of Nb36 on the RBD surface. g Nb17 stacks on NTD via its framework, while isolated Nb36:RBD complex indicates Nb36 would clash with neighboring NTD on S. h ACE2 competition assay with the S.