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. 2021 Jul 21;12:686502. doi: 10.3389/fphar.2021.686502

FIGURE 1.

FIGURE 1

Bicyclol markedly improved the liver enzyme, histology, and liver gross appearance in BDL mice. (A–F) Serum biochemistry including AST, ALT, ALP, GGT, TBA, and TC. (G) H&E stain liver histology (Scale bar, 100 um). (H) Gross liver appearance (Scale bar, 10 mm). AST, aspartate aminotransferase; ALT, alanine aminotransferase; ALP, alkaline phosphatase; GGT, γ-glutamyl transpeptidase; TBA, total bile acid; TC, total cholesterol. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001 vs. sham; # p < 0.05, ## p < 0.01, ### p < 0.001, #### p < 0.0001 vs. BDL.