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. 2021 Jul 21;8:708744. doi: 10.3389/fmed.2021.708744

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Copyright © 2021 Večerić-Haler, Kojc, Sever, Zver, Švajger, Poženel, Hartman, Urdih, Mlinšek, Oblak, Aleš Rigler, Ihan, Buturović Ponikvar, Halloran and Arnol.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Kidney graft function and serum concentrations of lymphocyte populations before and after application of mesenchymal stem cells. Three consecutive applications of mesenchymal stem cells are marked with arrows. eGFR, estimated glomerular filtration rate; mGFR, measured glomerular filtration rate (by Cr-EDTA); conc, concentration; Treg, regulatory T cells. (B) Cytokine concentrations after mesenchymal stem cells application (in U/mL for soluble interleukin 2 receptor and in pg/mL for other cytokines). Time frame of corticosteroid treatment is marked with arrows; Legend: TNF, tumor necrosis factor; IL, interleukin; s-IL-2-R, soluble interleukin 2 receptor; IFN, interferon.