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. 2021 Jul 21;12:707290. doi: 10.3389/fmicb.2021.707290

TABLE 2.

Clinical trials on OAd-based cancer vaccines.

OAd name Transgene Indication Combination therapy Clinical trial number Phase
ETBX-011 (Ad5 [E1-, E2b-]-CEA(6D) CEA Colon cancer Lung cancer Breast cancer NCT01147965 I/II
Neoplasms Prostate cancer Lung cancer Breast cancer Colon cancer ETBX-061 (Ad5 [E1-, E2b-]-MUC-1) ETBX-051 (Ad5 [E1-, E2b-]-brachyury) NCT03384316 I
Ad5-PSA PSA Hormone refractory prostate cancer NCT00583024 II
ETBX-071 (Ad5 [E1-, E2b-]-PSA) Metastatic castration-resistant prostate cancer ETBX-061 (Ad5 [E1-, E2b-]-MUC-1) ETBX-051 (Ad5 [E1-, E2b-]-brachyury) NCT03481816 I
Ad-MAGEA3 MAGE-A3 Advanced/metastatic solid tumor MG1-MAGEA3 NCT02285816 I/II
Non-small cell lung cancer MG1-MAGEA3, pembrolizumab NCT02879760 I/II