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. 2021 Jul 21;9:697947. doi: 10.3389/fcell.2021.697947

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Copyright © 2021 Inno, Kikas, Lillepea and Laan.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Expression dynamics of C19MC and C14MC miRNA clusters across gestation compared to the transcript levels of their miRTarBase target genes. Placental transcript levels were confidently quantified for 63/76 and 215/262 predicted target genes of C19MC and C14MC, respectively. (A) miRNA and gene expression levels during pregnancy presented in Z-scores; expression data for miRNAs is shown in red and for target genes in blue. (B) Heatmap and hierarchical clustering of miRNA–target gene expression data based on the calculated correlation coefficient Kendall tau.