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. 2021 Jul 21;9:697947. doi: 10.3389/fcell.2021.697947

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Copyright © 2021 Inno, Kikas, Lillepea and Laan.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Placental miRNA expression Quantitative Trait Loci (miR-eQTLs). Discovery analysis of single nucleotide variants (SNVs) modulating the expression of flanking miRNAs was carried out in 40 term placental samples and the most significant miR-eQTLs are presented. In each subgraph, miRNA normalized read counts (y-axis) are shown for samples stratified based on SNV genotypes (x-axis). Blue, red and green colors represent placentas homozygous for the major allele, heterozygous or homozygous for the minor allele of SNV, respectively. Additionally, distribution of genotype-stratified samples in the trimesters are shown. miRNAs that are also differentially expressed in term preeclampsia are indicated with an asterisk (*). Further details are presented in Supplementary Tables 1, 21, 33 and Supplementary Data 1. FDR, false discovery rate; FC, fold change.