TABLE 1.
Clinical characteristics of the pregnancies profiled for the placental miRNome.
| Early pregnancy |
Term pregnancy |
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| Pregnancy related parameters (units)/ | I trimester | II trimester | All samples | Healthy | Preeclampsia | Gestational diabetes | SGA at birth | LGA at birth |
| Sample size (n) | 5 | 7 | 40 | 8 | 8 | 8 | 8 | 8 |
| Maternal age (years) | 24 (19–33) | 24 (15–39) | 29 (18–39) | 33 (18–37) | 27 (19–39) | 33 (22–36) | 25 (20–32) | 30 (18–39) |
| Maternal height (cm) | 161 (160–165) | 170 (160–173) | 166 (153–179) | 165 (158–175) | 170 (163–173) | 167 (158–175) | 166 (153–172) | 167 (160–179) |
| Pre-pregnancy BMI (kg/m2) | 21 (20–26) | 22 (17–25) | 24 (16–43) | 24 (17–30) | 26 (20–34) | 26 (18–43) | 21 (17–24) | 24 (19–31) |
| Nulliparity (n, %) | 1 (20%) | 5 (65.5%) | 21 (52.5%) | 3 (37.5%) | 6 (75%) | 3 (37.5%) | 7 (87.5%) | 2 (25%) |
| Smokers (n) | 4 | Unknown | 7 (17.5%) | 2 (25%) | 2 (25%) | 1 (12.5%) | 2 (25%) | 0 |
| Gestational age at birth/abortion (days) | 60 (51–81) | 121 (108–140) | 274 (260–291) | 284 (260–291) | 266 (260–271) | 276 (268–284) | 271 (264–289) | 281 (275–288) |
| Vaginal/CS delivery | n.a | n.a | 19/21 | 5/3 | 2/6 | 3/5 | 6/2 | 3/5 |
| Fetal sex (M/F) | 2/3 | 4/3 | 19/21 | 5/3 | 4/4 | 3/5 | 3/5 | 4/4 |
| Birth weight (g) | n.a | n.a | 3756 (2004–4986) | 3756 (3102–4220) | 2803 (2170–3570) | 4284 (3940–4680) | 2517 (2004–2698) | 4744 (4420–4986) |
| Birth length (cm) | n.a | n.a | 51 (45–55) | 51 (49–55) | 48 (45–49) | 53 (51–54) | 46 (45–48) | 53 (52–55) |
| Birth head circumference (cm) | n.a | n.a | 35 (32–39) | 36 (33–36) | 34 (32–36) | 36 (34–38) | 32 (32–34) | 38 (37–38) |
| Birth chest circumference (cm) | n.a | n.a | 35 (28–39) | 35 (33.5–38) | 31 (28.5–35) | 36 (34–38) | 31 (28–34) | 37 (36–39) |
| Placental weight (g) | n.a | n.a | 545 (200–1060) | 575 (420–770) | 463 (340–720) | 588 (500–1060) | 420 (200–470) | 818 (610–970) |
Data are represented as medians with ranges, except where indicated differently. Nulliparity refers to no previous childbirth. Birth data apply to the newborn. BMI, body mass index; CS, C-section; LGA, large-for-gestational-age; SGA, small-for-gestational-age; n.a., not applicable.