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Senescence of CD8 T-cells is associated with phenotypic and metabolic changes. (A) Gradient of activation or function marker expression from naive (early differentiated) to senescent (terminal differentiated) cells. (B) Age-related metabolic changes of CD8 T-cells. (C) Events and signalling factors leading to the loss of TCR sensitivity that accumulate with age. ECAR, extracellular acidification rate; FA, fatty acid; NKR, NK receptors; sMAC, Sesn-MAPK activation Complex.
