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. 2021 Jul 21;9:723490. doi: 10.3389/fbioe.2021.723490

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Copyright © 2021 Cui, Wu, Wang, Zheng, Ou, Xu, Qu and Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The design of hydrogel by altering its physicochemical properties as delivery systems for cancer immunotherapy. (A) Loadable: ensure that the immune cargo can stay in the hydrogel when it does not need to be released. (B) Implantable and injectable: ensure that the hydrogel can reach the tumor site in a minimally invasive, non-surgical way and stays at the tumor site for drug release. (C) Degradable: hydrogel degrades for releasing the encapsulated drugs. (D) Stimulus-responsible: to achieve controlled release of the drugs from hydrogel upon external stimuli.