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. 2021 Jul 21;12:694204. doi: 10.3389/fendo.2021.694204

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Copyright © 2021 Yao, He, Cui, Wang, Bao, Huang, Wang and Liu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Signaling of 5-HTR2C in POMC neurons generating food intake. Activation of α_q/11 promotes phospholipase C (PLC) to produce diacylglycerol (DAG) and inositol-1,4,5-triphosphate (IP3). IP3 promotes release of intracellular calcium (Ca²⁺) while DAG binds to downstream effector protein kinase C (PKC), both of which activates c-Fos via the extracellular regulated kinase pathway (ERK). C-Fos turns on the pro-opiomelanocortin (POMC) promoter, which signals to neurons regulating the food intake signal. This signal is also regulated by 5-HTR2C agonist and serotonin.